![]() ![]() Outdoor gliders designed with these materials that are properly maintained will refrain best from fading, cracking, and rotting. It always helps if they have some type of coverage from direct sunlight and rain such as being stationed under an awning or porch. These types of outdoor gliders are normally more affordable and easier to move back and forth from the porch to the garage for off-season storage. You can find gliders in traditional styles, retro looks, rustic and farmhouse styles or cool modern designs. Different styles can often complement one another, and your outdoor patio, porch, or deck decor can help blur the lines between indoor and outdoor seating by selecting the right chair or bench glider that best balances your existing outdoor seating scheme. Spray-dried monohydrate lactose is generally recommended for direct compression/dry granulation, but we observed that it showed advantages in the wet granulation tableting method for low-dose tablet formulation.Ĭontent uniformity (CU) is a crucial evaluation factor, especially for low-dose oral formulations.From Adirondack-style glider benches and chairs to the classic outdoor gliders ranging in styles from vintage to contemporary, you're sure to find the one that best suits your style. In this study, several commercial brands of lactose were selected and suitable tableting methods were applied to a low-dose oral formulation of pentyloxyl paliperidone derivative (PD6) with drug loading at 1.5% (w/w) and lower. The effects of spray-dried/sieved/milled monohydrate and anhydrous lactose on CU were investigated. Granules/powder mixtures were studied in terms of their size distribution, repose angle, flowability and bulk/tapped density. In addition, SEM, DSC, CU, tablet weight, hardness, friability and in vitro cumulative release profiles were investigated. The relationships between the powder characteristics and CU results were also studied. ![]() Wet granules using spray-dried lactose monohydrate presented satisfied flowability, fair compressibility and a low particle size span compared with all the other tested types of lactose. The product tablets also presented optimal evaluation results for 1.5% (w/w) drug loading (CU = 12.22) and displayed good repeatability among 100 g to 2 kg levels. Further study using another two brands of lactose produced similar results, indicating using spray-dried monohydrate lactose in wet granulation may apply universally to low-dose formulations.1. A method for making a tablet having a diameter, as determined by the longest enveloping circle, in the range of 1 to 5 mm and/or a weight in the range of 1 to 100 mg, the method comprising: (a) obtaining a lactose agglomerate comprising lactose and a sugar alcohol (b) obtaining an active ingredient selected from the group of pharmaceutical substances and active substances for dietary supplements or nutraceuticals (c) mixing the agglomerate and the active ingredient, thereby obtaining a mixture and (d) forming the mixture into the tablet by direct compression.Ģ. The method according to claim 1, wherein the sugar alcohol is selected from the group consisting of lactitol, maltitol, sorbitol, mannitol and erythritol.ģ. The method according to claim 1, wherein the tablet comprises at least 20 wt. %, based on total weight of the tablet, the active ingredient.Ĥ. The method according to claim 3, wherein the tablet comprises 30-80 wt. ![]() %, based on total weight of the tablet, the active ingredient.ĥ. The method according to claim 1, wherein (a) the agglomerate is obtained by spray-agglomerating, wherein lactose particles in powder form are agglomerated with an aqueous binding solution comprising the sugar alcohol and optionally a water soluble carbohydrate.Ħ. ![]() The method according to claim 5, wherein the carbohydrate is lactose.ħ. The method according to claim 1, wherein the weight to weight ratio of lactose to sugar alcohol in the agglomerate is in the range of 80:20 to 99:1.Ĩ. The method according to claim 7, wherein the weight to weight ratio of lactose to sugar alcohol in the agglomerate is in the range of 90:10 to 97:3.ĩ. The method according to claim 1, wherein the agglomerate comprises 70-99 wt. The method according to claim 9, wherein the agglomerate comprises 75-95 wt. ![]()
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